2025, Vol. 6, Issue 2, Part E

Background: Enterobius vermicularis is a frequent helminthic infection in children that provokes a significant immune modulation, in particular, Th2-type immune responses.

Aims of the study: The purpose of this paper was to test the immune response markers as the indicator of the symptom severity, in children infected with Enterobius vermicularis, and to study the correlation between them and with clinical manifestations and inflammatory condition.

Methodology: The case Control study was a hospital-based case study, which was carried out between March 20 and September 5, 2025, and involved 100 children; 75 of them had confirmed Enterobius vermicularis infection, and 25 were healthy controls. Perianal adhesive tape test was used to make a diagnosis and the degree of symptoms was clinically graded. Blood samples (venous) were taken to have complete blood count and serum tests. ELISA was performed to determine the association between immune markers (IgE, IL-5, IL-10, IFN- γ and hs-CRP) and the severity of the symptoms.

Result: Enterobius vermicularis infection in children did not have significant differences with controls in terms of age, sex, BMI, or residence, which means that groups are homogeneous. Nevertheless, nocturnal pruritus and sleep disturbance scores, and symptom severity scores were significantly larger in patients. Th2-biased immune response was shown in infected children with increased eosinophils, IgE, IL-5, IL-10, and hs-CRP, and decreased IFN-γ. These immune markers rose in direct proportion to the severity of the symptoms and had a great correlation with clinical burden, which is evidence that these are predictive.