2025, Vol. 6, Issue 2, Part D
Prodigiosin biosynthesis by Serratia nematodiphila: Bioprocess engineering for enhanced yield
Author(s): Nandana Nath PG, Mabel Merlen Jacob and Dhanya KC
Abstract: Prodigiosin is a red colored tripyrrole bacterial pigment with a wide range of promising biological activities, including potent anticancer, antibacterial, antifungal, and anti-inflammatory properties, and thus possess potential applications in medicine and biotechnology. While Serratia marcescens is a well-known producer, this investigation explored a different and less common source: Serratia nematodiphila. The S. nematodiphila strain was isolated from dry coconut and its identity was confirmed through 16S rRNA gene sequencing. Bioprocess parameters such as carbon source, nitrogen source, pH, etc, were optimized using Response Surface Methodology (RSM). Further works were done to evaluate novel, cost-effective substrates, including diverse agro-industrial wastes (e.g., rice water, sugarcane juice, whey, fruit peels) and oils (e.g., castor oil, palm oil, coconut oil, etc.) for their suitability for supporting Serratia growth and enhanced prodigiosin biosynthesis.
DOI: 10.22271/micro.2025.v6.i2d.276
Pages: 348-355 | Views: 76 | Downloads: 33
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How to cite this article:
Nandana Nath PG, Mabel Merlen Jacob, Dhanya KC. Prodigiosin biosynthesis by Serratia nematodiphila: Bioprocess engineering for enhanced yield. J Adv Microbiol Res 2025;6(2):348-355. DOI: 10.22271/micro.2025.v6.i2d.276
