2025, Vol. 6, Issue 2, Part C
Role of IL-8 in urinary tract infection among diabetic and non-diabetic patients
Author(s): Alaa Jassim Ali and Nihad Abdul-Hussein Jaafar
Abstract: Urinary tract infection (UTI) is one of the most common problems among women and men. The infection is mostly bacterial and occurs when a microorganism invades the lining of the urinary tract. Patients with diabetes are at increased risk of infection, especially UTIs. A high level of sugar leads to a change in the immune function of diabetic patients, which is closely related to many innate and adaptive immune system defects, which may lead to an increased risk of developing a urinary tract infection. The change in immune function may appear in the form of a decrease in the levels of some motors such as IL-8. Urinary and blood samples were collected from 73 UTI patients who had diabetes and 45 UTI patients who did not have diabetes. The bacterial types that cause UTI were diagnosed in both groups and compared with the control group (20 samples for healthy people), and a study was conducted the relationship of the high level of this immune cytokine with the type of bacterial infection. The level of interleukin-8 in this study was (3.5 ± 16.80) pg/ml compared to the control samples, which amounted to (1.45 ± 9.48) pg/ml, while its level in diabetic patients with urinary tract infection was (3.77 ± 15.86) pg/ml. ml, compared to the control samples (2.11 ± 9.64) pg/ml. The most pathogenic cause of UTI patients and diabetics was E.coli (28.50%), and its percentage was in UTI patients without diabetes (31.42%).
DOI: 10.22271/micro.2025.v6.i2c.253
Pages: 201-206 | Views: 100 | Downloads: 24
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How to cite this article:
Alaa Jassim Ali, Nihad Abdul-Hussein Jaafar. Role of IL-8 in urinary tract infection among diabetic and non-diabetic patients. J Adv Microbiol Res 2025;6(2):201-206. DOI: 10.22271/micro.2025.v6.i2c.253
