2025, Vol. 6, Issue 1, Part D
Prevalence and genetic basis of high-level aminoglycoside and fluoroquinolone resistance in enterococcus isolates from urinary tract infections in Dhaka, Bangladesh (July 2022-June 2023)
Author(s): Mousumi Tania, SM Shamsuzzaman, Muhammad Nurul Huda Khan and Amena Khatun
Abstract: This study investigated high-level aminoglycoside and fluoroquinolone resistance in Enterococcus isolates from urinary tract infections (UTIs) at a tertiary care hospital in Dhaka, Bangladesh, between July 2022 and June 2023. Out of 37 identified Enterococcus species, mostly Enterococcus faecalis, 62.16% were multidrug-resistant. Significant resistance was observed for gentamicin (54.05%) and ciprofloxacin (59.46%), though all isolates were susceptible to vancomycin and linezolid. High-level gentamicin resistance (HLGR) was present in 48.65% of isolates, with the aac(6’)-Ie-aph(2")-Ia gene being most common (83.33%). Among ciprofloxacin-resistant isolates, gyrA mutations were found in 81.82% and parC mutations in 72.73%. These findings underscore the widespread antimicrobial resistance in Enterococcus species in Dhaka, emphasizing the urgent need for robust antibiotic stewardship and continuous surveillance to combat this growing public health threat.
DOI: 10.22271/micro.2025.v6.i1d.224
Pages: 293-298 | Views: 487 | Downloads: 53
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How to cite this article:
Mousumi Tania, SM Shamsuzzaman, Muhammad Nurul Huda Khan, Amena Khatun. Prevalence and genetic basis of high-level aminoglycoside and fluoroquinolone resistance in enterococcus isolates from urinary tract infections in Dhaka, Bangladesh (July 2022-June 2023). J Adv Microbiol Res 2025;6(1):293-298. DOI: 10.22271/micro.2025.v6.i1d.224
