2024, Vol. 5, Issue 2, Part C
Molecular characterization and antifungal sensitivity pattern of fungi species isolated from presumptive tuberculosis patients in university of port Harcourt teaching hospital
Author(s): Victoria Baadom, LO Amadi, T Sampson and O Aleruchi
Abstract: Tuberculosis (TB) and Mycoses has been around for centuries and remains a major health concern globally with its diverse environmental conditions and population dynamics, possess a unique epidemiological scenario for TB and its associated co-infections. This study was therefore aimed to molecularly character is Sputum specimens from 350 participants were collected and analyzed using molecular and conventional diagnostic methods for fungi. Antifungal susceptibility test was performed using the Kirby-Bauer Disc Diffusion method. The Molecular identification of fungal species isolated from presumptive TB patient used in this revealed diversity of fungal species such as Curvularia caricae-papayae, Psudopithomyces chartum, Aspergillus udagawae, Penicillium sp. Trichoderma longibrachiatum, Candida albican, Cutaneotrichosporon curvatum, Trametes polyzona and Aureobasidium pullulans. The results of antifungal profile of fungal isolated revealed that all the fungal isolates were susceptible to Ketoconazole except Aspergillus udagawae, the isolates also showed 100% susceptibility to Fluconazole except Trichoderma longibrachiatum and Candida albican that shown 100% resistant and intermediate, respectively to Fluconazole. Curvularia caricae-papayae, Aspergillus udagawae, Penicillium sp. and Trametes polyzona showed 100% resistant to itraconazole while Psudopithomyces chartum, Aspergillus udagawae, Cutaneotrichosporon curvatum and Aureobasidium pullulans revealed 100% resistant to Nystatrin. The study suggests the necessity for a dual-focused health strategy addressing TB, fungal infections co-infection. Furthermore, the variability in antifungal susceptibility profiles highlight the importance of individualized treatment plans based on local resistance patterns. This research contributes to bridging diagnostic and treatment gaps in TB, fungal infections co-infection, offering insights for refining public health interventions and optimizing patient care in Port Harcourt and similar settings.
Pages: 236-241 | Views: 43 | Downloads: 20
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How to cite this article:
Victoria Baadom, LO Amadi, T Sampson, O Aleruchi. Molecular characterization and antifungal sensitivity pattern of fungi species isolated from presumptive tuberculosis patients in university of port Harcourt teaching hospital. J Adv Microbiol Res 2024;5(2):236-241.
