2024, Vol. 5, Issue 2, Part B
Current understanding on yellow fever and its serious impact on global health
Author(s): Mahendra Pal, Firaol Tariku Geleto, Tesfaye Rebuma, Sujatha Singh, Satyam Sejra
Abstract: Emerging and re-emerging zoonotic diseases pose significant global health challenges at the national and international organizational levels, severely affecting the human and animal populations. Among the vector-borne diseases, the deadliest mosquito-borne disease is yellow fever, which is endemic to tropical areas of Africa, Central America, and South America. Yellow fever is a viral hemorrhagic fever that strikes an estimated 200,000 persons worldwide each year and causes an estimated 30,000 deaths annually. It poses a substantial threat to unvaccinated people traveling to the endemic regions. Yellow fever follows the epidemiological transmission channel: the sylvatic, urban cycle, and an intermediate cycle that bridges these two patterns, and symptoms in humans progress from mild flu-like signs to severe hemorrhagic fever, jaundice, and deaths up to 60% primarily affecting humans and primates. Several contemporary social and demographic shifts, such as population growth, international migration, deforestation, and changes in land use, have increased the likelihood of these diseases spreading to new areas. The plaque-reduction neutralization test is the most reliable method for distinguishing yellow fever from other flaviviruses. Despite the lack of specific antiviral treatments, supportive care can mitigate symptoms, and effective preventive measures, including vaccination and vector control, are crucial for managing outbreaks of yellow fever. Enhanced surveillance systems, improved laboratory capacities, and continued research on the pathogenesis and chemotherapy of yellow fever are essential.
Pages: 125-130 | Views: 164 | Downloads: 75
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How to cite this article:
Mahendra Pal, Firaol Tariku Geleto, Tesfaye Rebuma, Sujatha Singh, Satyam Sejra. Current understanding on yellow fever and its serious impact on global health. J Adv Microbiol Res 2024;5(2):125-130.