2024, Vol. 5, Issue 1, Part A
Isepamicin and other antibiotics comparative activity against gram-negative bacilli
Author(s): Dr. Krishna Kumar Patel and Dr. Sarita Patel
Abstract: The in vitro activity of isepamicin was compared to that of amikacin, gentamicin, cefepime, ciprofloxacin and meropenem against Gram-negative bacilli isolated from patients hospitalized in the intensive care unit (ICU). The minimal inhibitory concentrations (MIC) for 1087 non-duplicate, consecu- tive aerobic Gram-negative isolates, including 797 Enterobacteriaceae and 289 non-fermenters, were deter- mined by E-test for each antibiotic. Overall, isepamicin was active against 91% of all isolates and was found more active than ciprofloxacin (84% susceptibility), gentamicin (88% susceptibility), cefepime and amikacin (89% susceptibility each), but less active than meropenem (94% susceptibility). Enterobacter aerogenes isolates exhibited the highest resistance rate to ciprofloxacin (72%) while P. aeruginosa appeared the most resistant (frequently multi-resistant) pathogen. Compared to amikacin, MIC values for isepamicin were usually two to fourfold lower for most inducible Enterobacteriacieae species and for Klebsiella spp., while they were identical for P. aeruginosa and other non-fermenters. Complete cross-susceptibility or cross- resistance between amikacin and isepamicin was observed in more than 95% of all tested isolates. On the other hand, 12% of all E. aerogenes isolates appeared resistant to amikacin and susceptible to isepamicin, while 6% of the P. aeruginosa were found to be resistant (or intermediate) to isepamicin and intermediate (or susceptible) to amikacin. No significant differences in pathogen distribution nor in resistance rates were observed between hospitals except for P. aeruginosa. Taking into account the species distribution and the prevalence of resistance to the different antibiotics tested, isepamicin appears as a suitable agent for empiric therapeutic use in severe ICU-acquired Gram-negative infections in India.
Pages: 08-14 | Views: 119 | Downloads: 54
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How to cite this article:
Dr. Krishna Kumar Patel, Dr. Sarita Patel. Isepamicin and other antibiotics comparative activity against gram-negative bacilli. J Adv Microbiol Res 2024;5(1):08-14.
