2023, Vol. 4, Issue 2, Part B
Effects of probiotic Lactobacillus species on the kidney and liver tissues of type 2 diabetic mice
Author(s): Esezi-Ovila O, Akani NP, Amadi LO and Ugboma CJ
Abstract: Type 2 Diabetes mellitus (T2DM) is a metabolic disease which causes severe damage to the liver and kidneys. This study aims to assess the effect of probiotic Lactobacillus species on the liver and kidney tissues of T2DM mice. Streptozotocin-induced diabetic male mice were treated with probiotic Lactobacillus species (1 x 109 CFU/mL) while the non-diabetic control group was given placebo for the treatment period. After four weeks of treatment, the mice were made to fast, after which they were weighed and anesthetized. Their liver and kindey samples were removed, weighed and used for histological analsis. The liver and kidney index was also calculated. The mice treated with Lactobacillus had liver index ranging from 4.12±0.2% – 4.69±0.3% which was significantly (p<0.05) lower than the liver index of the diabetic control group (5.41±0.2%). On the other hand, the kidney index of the Lactobacillus treated mice ranged from 1.31±0.2% to 1.51±0.1% which was significantly (p<0.05) lower than the kidney index of the diabetic control group (1.68±0.1%). The findings of this study show that probiotic Lactobacillus species were able to reverse glomerulosclerosis and glomerulonephritis in the kidneys, and focal necrosis in the liver of the T2DM mice. Thus, probiotic Lactobacillus species were able to improve liver and kidney disorders in T2DM mice.
DOI: 10.22271/micro.2023.v4.i2b.117
Pages: 140-147 | Views: 278 | Downloads: 95
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How to cite this article:
Esezi-Ovila O, Akani NP, Amadi LO, Ugboma CJ. Effects of probiotic Lactobacillus species on the kidney and liver tissues of type 2 diabetic mice. J Adv Microbiol Res 2023;4(2):140-147. DOI: 10.22271/micro.2023.v4.i2b.117
