2021, Vol. 2, Issue 2, Part A
Antiulcerogenic activity of Panicum maximum root extract
Author(s): Jude E Okokon, Abasiifreke Pius Felix, Patience J Okokon and Emoleila Itoandon
Abstract: Root extract of Panicum maximum is used in Ibibio traditional medicine for the treatment of various ailments including diabetes mellitus, malaria and gastrointestinal disorders. The study aimed to evaluate the antiulcerogenic activity of the root extract against experimentally-induced ulcer in rats. Ethanol root extract of Panicum maximum (137-547 mg/kg) was investigated for antiulcerogenic activity against indomethacin, ethanol and histamine-induced ulcers in overnight fasted wistar rats weighing 125-150 g. the rats were randomized into different groups and treated with extract and ulcerogens. The stomachs of the animals were removed, examined for ulcerations and scored accordingly. The root extract (137-547 mg/kg) was found to exert significant (p<0.05-0.001) and dose-dependent activity against indomethacin, ethanol and histamine-induced ulcers. These results suggest that the root extract of Panicum maximum possess antiulcerogenic potential which is due to the activities of the phytochemical constituents which can be explored for the treatment of ulcers.
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How to cite this article:
Jude E Okokon, Abasiifreke Pius Felix, Patience J Okokon, Emoleila Itoandon. Antiulcerogenic activity of Panicum maximum root extract. J Adv Microbiol Res 2021;2(2):05-08.